Side Reactions In Organic Synthesis: A Guide To Successful Synthesis Design Broché

Présentation de l'éditeur Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure–reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success–rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium–Catalyzed C–C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates Revue de presse \"...I enjoyed reading this book and will refer to it often to help understand problem reactions. Highly recommended...\" Organic Process Research & Development \"The text in this book is clear, and the diagrams are well presented. There are lots of references, with titles making it easier for the reader to access the value of a reference before they go to find it. The author has worked hard on this book and made a brave effort. Overall, though, it is one for research libraries, but does not merit a personal investment, in my opinion.\" Journal of the American Chemical Society \"The book should be required reading for all who believe that making molecules is an easy task. If, after reading it, they still consider that our organic synthesis is a worked–out branch of science, they must go to the laboratory and try to do it themselves.\" Miguel A. Sierra, Universidad Complutense, Madrid Angewandte Chemie 2005–117/29 + International Edition 2005–44/29 \"The text in this book is clear, and the diagrams are well presented. There are lots of references, with titles making it easier for the reader to assess the value of the reference...\" ( Journal of the American Chemical Society, May 25, 2005) \"...I enjoyed reading this book and will refer to it often to help understand problem reactions. Highly recommended...\" (Organic Process Research & Development) Quatrième de couverture Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure–reactivity relationship of organic compounds. This advanced textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success–rate. A must for every student but also for every chemist in industry and academia. From The Contents: Organic Synthesis: General Remarks Stereoelectronic Effects and Reactivity The Stability of Organic Compounds Aliphatic Nucleophilic Substitutions: Problematic Electrophiles The Alkylation of Carbanions The Alkylation of Heteroatoms The Acylation of Heteroatoms Palladium–Catalyzed C–C Bond Formation Cyclizations Monofunctionalization of Symmetric Difunctional Substrates Biographie de l'auteur F. Zaragoza Dörwald studied chemistry at the Georg–August University of Göttingen and Université Louis Pasteur, Strasbourg, where he obtained his Ph.D. in 1990 on the synthesis of natural products under the guidance of M. Franck–Neumann and M. Miesch. He spent each one postdoctoral year in the groups of A. Pfaltz (University of Basel) and A.P. Marchand (University of North Texas), and worked